Adverse effects of topically applied anesthetics include but are not limited to:

1. Variable systemic absorption and potential systemic toxicity if applied to large areas of the skin or to dermabraded skin
2. Systemic toxicity of anesthetics may lead to CNS stimulation and/or depression (seizures, respiratory arrest) and cardiovascular depression (low heart rate, hypotension, arrhythmias) that may result in coma and death
3. Burning or stinging sensation at the administration site

1. • Skin discoloration
   • Swelling
   • Tissue necrosis and sloughing
   • Methemoglobinemia (with topical prilocaine)
   • Topical or systemic allergic reaction